First use of insulin on human for treatment of diabetes

First use of insulin on human for treatment of diabetes

On this day in 1922 the insulin was used for the very first time to treat diabetes. 

Sir Frederick G, Banting,Charles H Best and JJR Macleod discovered insulin in 1921 at the university of Toronto while James B Collip had purified it. Prior to 1921 it was hard got people with Type 1 diabetes to live more than a year or two. It continues to remain one of the greatest medical discoveries and one of the most efficient methods of treatment till date.

It all started when a 14 year old boy named Leonard Thompson, lay dying at the Toronto General Hospital, on 11th January and was given the first injection of insulin. However, the extract of insulin was very impure and led Thompson to suffer from a severe allergic reaction, causing further injections to be cancelled. 

James Collip worked over the next 12 days to purify the ox-pancreas extract, and a second dose was injected on the 23 January. This was completely successful, not only in having no obvious side-effects, but in completely eliminating the glycosuria sign of diabetes.

To each of the 50 children kept in each ward  suffering from diabetic ketoacidosis (DKA) were injected with the purified extract by Banting, Best, and Collip. Before they had reached the last dying child, the first few were awakening from their coma, to the joyous exclamations of their families.